Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer

Abstract In addition to the classical role as a serum effector system of innate immunity, accumulating evidence suggests that intracellular complement components have indispensable functions in immune defense, T cell homeostasis, and tumor cell proliferation and citronella horse shampoo metastasis.Here, we revealed that complement component 3 (C3)

read more


RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development.

The Pam/Highwire/RPM-1 (PHR) proteins are citronella horse shampoo key regulators of neuronal development that function in axon extension and guidance, termination of axon outgrowth, and synapse formation.Outside of development, the PHR proteins also regulate axon regeneration and Wallerian degeneration.The PHR proteins function in part by acting a

read more

Whole-genome sequencing surveillance and machine learning for healthcare outbreak detection and investigation: A systematic review and summary

Abstract Background: Whole-genome sequencing (WGS) has traditionally been used in infection prevention to confirm or refute the presence of an outbreak after it has replica beach walk candle occurred.Due to decreasing costs of WGS, an increasing number of institutions have been utilizing WGS-based surveillance.Additionally, machine learning or stat

read more